Onyije F

Objective: This is to evaluate the effect Mangifera indica effects on the liver. The fruit of Mangifera indica is a major source of food for man and animal. The leaf, root and stem bark are widely used for medicines. Mangifera indica is used medicinally to treat ailments such as asthma, cough, diarrhea, dysentery, leucorrhoea, jaundice, pains, malaria, diabetes, asthma, infertility, lupus, prostatic hyperplasia, gastric disorders, mouth sores and tooth pain. Method: Twenty (20) wistar rats of both sexes (150-200g) were used, they were randomly divided into 4 groups of five (5) each and tested as follows: Group Ocontrol (distilled water), Group A M. indica extract (1.0 ml/kg, orally), Group B M. indica extract (1.5 ml/kg, orally), Group C – M. indica extract (2.0 ml/kg, orally). Each ml contains 0.11g of the extract. After 21days of treatment the livers were dissected for Histological examination. Result: The Histological sections of the liver shows normal tissue architecture, no form of cell distortion as the tissue architecture are well preserved. Conclusion: This could be dose dependent and may show effect in higher doses, therefore caution should be applied when using higher doses of Mangifera indica extract for treatment or preventive purposes.